Description
Prostaglandins are known to affect the nervous system and can modulate synaptic transmission and neurotransmitter release, the sleep/wake cycle, fever, pain, and the immune system. Prostaglandin E2 receptor, EP1 subtype (EP1/PTGER1) is a receptor for prostaglandin E2 (PGE2). The members of the EP receptor family, EP1, EP2, EP3, and EP4, elicit their actions by altering cyclic adenosine monophosphate (cAMP) or intracellular calcium concentrations. EP1 activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium via a Gi/Gq-coupled mechanism. EP2 and EP4 both signal through a Gs-coupled mechanism that stimulates adenylyl cyclase and increases intracellular levels of cAMP. EP1 appears to mediate the effects of PGE2 in promoting the formation of precancerous lesions in animal models of colon cancer. In addition, EP1 has an inhibitory effect on stress-induced aggressive and risk-taking behaviors in mice. |
Synonyms
Human Recombinant EP1 Prostanoid Receptor Stable Cell Line
Applications |
Functional assay for EP1 receptor |
Storage |
Liquid nitrogen immediately upon delivery |
Species |
Human |
Freeze Medium |
45% culture medium, 45% FBS, 10% DMSO |
Culture Medium |
DMEM, 10% FBS, 200 μg/ml Zeocin, 250 μg/ml G418 |
如您需要获取细胞系产品的说明书,请点击“Manual”,完善信息后点击“提交”。
我们会第一时间联系回复您。注意:中国地区购买的产品,说明书需要以中文站为准。
您也可拨打400-0258686转5810,或发邮件至product@lishanghui.com163am银河线路娱乐官网。
更多产品文件类型 >>