Description
CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.<br/> The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans. |
Synonyms
ALPS5; CD; CD152; CELIAC3; GRD4; GSE; IDDM12
Applications |
Binding assay or use as immunogen. |
Storage |
Liquid nitrogen immediately upon receiving |
Species |
Human |
Stability |
15 passages |
Freeze Medium |
95% complete growth medium, 5% (V/V) DMSO (Cat. #D2650, Sigma) |
Culture Medium |
F-12K (Kaighn’s), 10% FBS, 8 μg/ml Puromycin (Cat. #A11138-03, Gibco) |
FACS analysis of CTLA4 expression in CHO-K1/CTLA4 cells.
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