Description
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein that in humans is encoded by the PDCD1 gene.PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells). |
Applications |
Binding assay or use as immunogen |
Storage |
Liquid nitrogen immediately upon receipt |
Species |
Mouse |
Stability |
15 passages |
Freeze Medium |
95% complete growth medium, 5% DMSO |
Culture Medium |
F12K, 10% FBS, 8μg/ml Puromycin |
Figure 1. FACS analysis of mouse PD-1 expression in CHO-K1/mPD-1 cells.
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